A comfortable saddle is one that supports your sit-bones firmly and relieves pressure on the squishy bits inbetween.
The width between sitbones and the vertical difference between bones and squishy bits varies from person to person so saddle profile will vary.
My own fav saddle is a very old Specialized that is very hard and looks normal. I prefer it to my San Marco Rolls ( a longtime fav of pro riders) and even to my Brooks B17.
Some saddles have a central cutout which some people like.

Hand comfort depends on having the correct reach to your bars in height and length, then on having a comfortable, neutral wrist angle. Any tension or torsion will soon affect you. Road drops are very good but you have a hybrid and trekking bars are sufficiently good for round the world tourists and a straight swap for you.

You need to setup the bike position for comfort and efficiency. Check out the best guide to bike fit.