40lbs??? Mavic 719 ,319, Alex Adventurer w. 36 spokes and the front wheel can be anything, hub doesn't matter. I'm not a fan of Velocity Synergy or Dyad because the seams are inconsistent and can be grabby.
Honestly a $100 Handspun wheel with Mavic 319 and straight 14g. spokes is a good wheel. It's what I have under my fat 220lb ass on before adding panniers.