Well, my 26" bikes have v brakes, which deliver huge stopping power. 26" wheels seem to be more stable in true, or a quick adjustment on the bike pulls them into lateral true. I don't recall any of my 26" wheels needing radial truing. You can also lower the pressure on big tires wihout having the same concern about pinch flats, at least me, or go max pressure and get them to roll fairly fast. And, lower center of gravity, more stable with weight..is good for potholed roads and crosswinds. That seems to me to be the pluses.