I'm running a 46/18 for 67.21/2.56 currently. I'll step down to a 46/16 to break 78.90 in a month or so, depending on traffic. I'm pretty content with the 46 I have currently and don't foresee changing it on my Handsome. However, the bike I've got on my radar in June has a 42/16 setup, so that may very well be swapped to a 48/15, all things considering.