I'm using Sidi Genius 5 Mega shoes and they're not bad. Used some Shimanos for 10 or so years. They weren't bad. But I guess after a couple of hours my feet must swell significantly because they are my first discomfort point. Long before my ass or hands.

I have been thinking for years I should probably get some custom shoes but I've never got around to A) justifying the money and B) having the patience to wait for delivery.