Yes, definitely consider tire size vs. frame and fender clearance now. I'm riding my city-fied Raleigh Grand Prix with 700 x 28s, but life would've been much easier if I had started with with a frame that had a longer wheelbase and better tire clearance. Raceblades work, but they bounce around a bit, especially the rear. Rack and fender bosses may not be essential, but they sure look better than the workarounds.