Originally Posted by
SweetLou
Unless Shimano has changed from an internal cam quick release to an external, you should be fine. If they did change (I don't think they have), then just get a good Shimano internal cam quick release. The clamping force of the quick release is what is suppose to hold the wheel in place, not the hub axle. So, it does need to be tight. Before vertical dropouts were common, many of us have used quick release without any problems what-so-ever.
The only time you might have a problem is if the clamp is directly over a stay and you can't get your fingers around the lever. Just make sure the lever is far enough away from a stay. But even if that happens, a tire lever gives enough leverage to pull it out.
This^^ Shimano QR's have enough clamping force to hold it just fine, some of the external cam QR's do not. If you have shimano's and are still having issues you can check out the DT RWS skewers, they are about as close to the clamping force of a bolt on wheel as you can get.