Back to basics
Frame size, fit correct?
Seat post height for proper extension. Saddle level.
Seat fore/aft to get knee position correct w/regard to pedal spindle.
Correct reach for comfortable balanced hand position.
Raise/lower bars accordingly with spacers for threadless steerer or quill height for threaded. Replace stem?
Adjust saddle tilt for balance.
Readjust seat post as necessary to correct for tilt adjustment.
Ride. Adjust again to fine tune.