I ride through a lot of manufacturing areas, so there is a lot of road debris like glass, small metal shavings, screws, nails, misc metal objects. I have had Specialized Fat Boy "Flak Jacket", Continental Gatorskins, and Armadillos and gotten flats with them all. It wasn’t until I started using tire liners that my frequency of flats went down.

When the Gatorskins wear down, I’m going to stick with a cheaper tire and just use liners.

Slime sucks, avoid that stuff. I tried Slime once and not only did it not plug the hole, it created a green mess when changing the tire, and clogged up the valve stem.