Has anyone suggested the salsa fargo yet? Disc brakes. Able to take knobby and wide tires. Fender and rack mounts (if needed). Drop bars if you want to go aero (and will take narrower slick tires). Could go with the vaya too, but the fargo looks like it'd be the best of all the worlds people seem to want.
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Bikes: 1996 Eddy Merckx Titanium EX, 1989/90 Colnago Super(issimo?) Piu(?), 1990 Concorde Aquila(hit by car while riding), others in build queue "when I get the time"