I have a set of Gatorskins with a wire bead. I have no issues with running them, except they are 25mm, and as such do not clear the seatstay on my Corima by enough for my satisfaction, so I run them on my Wilier mostly. It's a very light build, and the difference in overall weight between the wire bead Gatorskins and a set of GP4000s on the same wheels/bike is remarkable, both when picking the bike up and riding it. That being said, in the winter I ride the Gatorskins quite happily.