There is no more personal relationship between a man and his saddle. Marriage comes a very close second.

With that said a good LBS will have a saddle demo program or a saddle selection that has a comfort guarantee. With dozens of saddle choices out there the chances of hitting the mark the first time is hard. The Fizik Alliante has been pretty popular from what I've seen but at my LBS, Bontrager has been pretty good as well as Selle Italia.