Originally Posted by Bob Dopolina

Do a search on KOPS (Knee Over Pedal Spindle). Although some will disagree with this as an absolute I believe it is a good, neutral place to start and then personal adjustments can be made from there. For instance I am slightly behind my pedal spindle because of the ratio between my femur and tibia puts me there.

However you go about setting up your saddle keep in mind that adjustments to the saddle are made for your lower body and bars and stems are adjusted for your upper body. In short, don't move your saddle to fit your upper body.