I kick off my 7 miles each way commute @ 0430. It's nice and quiet and there aren't too many cars. No one's been rude, too early I guess and the most activity I run into is road work.
The only thing I hate about that time of the day is having to use the crosswalk light at intersections because there are no cars to turn the lights for me.
I use an old NR HID headlight up front, a Coast Guard life preserver strobe and LED blinkie in the rear plus lots of reflective stuff.