Well I've dropped 50 Lbs in 5 months, I'm basically hitting the gym 5 days a week and watching what I eat. The most effective thing *for me* has been interval training (basically do the hardest cardio you can for a minute or two to get your heart rate up, then give it a few minutes to come all the way down, then go hard again).
As for supplements, I'm taking GNC Mega-men sport vitapaks (Basically a multivitamin plus some natural supplements), 4000mg of CLA per day (half with breakfast, half with dinner), and 500mg of L-Carnitine per day. Again, this is working for me and won't necessarily work for you.
Good luck!