My bikes go into the back of my Honda CRV without having to take off the wheels. It's literally 5 seconds to chuck a bike into the car. I rarely have passengers so the Honda's back seats are kept folded down and I have a flattened piece of a cardboard bike box that the bike just slides on - that keeps the upholstery clean and un-snagged. A foam pool noodle fits under the handlebars to prevent the bar ends/tape from rubbing against the cardboard.
I can fit two road bikes stacked in a pile in the back with another piece of cardboard separating the two bikes so they don't tangle.
Perfect for when I plan to ride directly after work, when I run errands before/after my bike ride, or other situations when the bike+car are unattended. It's nice not worrying about the removable accessories too - lights/batteries, saddlebag, heart rate monitor and computer.
Also, some friends had a rooftop rack stolen (bike not in rack) - it was an expensive rack and the thieves damaged the car. The bike rack I used on my 2-seater convertible didn't fit the Honda. Why buy a new rack for $$$ when I can avoid the nuisance of mounting a rack before rides then removing it when I don't need it?