I have a Crumpler Meat Smuggler and a Crumpler Gentleman Farmer that I'm quite happy with, but their slightly expensive but they come with a 30-year guarantee. I use them why my gf makes me carry her BlackBook (13.3") home/to work.
when I need to move a lot of stuff ... I go with a 75L Kajka rucksack from Fjällräven and it's not so bad on the bike
all 3 are costly up-front but worth their money over time. The FJ was super-expensive (2400SEK = roughly 400 USD) but it's been very useful over the 5 years of trekking.