Big John,
I think this is more true than most believe. Not a cover all answer but for a few, like me I believe it is the case. I have to take more fluids and eat bananas more while running (I miss those days badly) or riding to escape cramps. My father was the same way with his calves, mine is the quads, too. Wonder if this has been studied so I could read up on what others do for the problem. Interesting idea to me.

Bill