Have a large Timbuk2, a medium Timbuk2 that doesn't get as much use, a Mission Workshops Rummy that is fantastic, and a pair of Ortlieb Classic Rollback panniers. I like the large capacity of the large Timbuk2, but the strap design is way outdated. With large loads, the pannys are the way to go, specially at longer distances. Shorter distances, the MW Rummy has a definite advantage in comfort, and the quality is superb. I'm working at getting a Seagull and a Dank.