Hey mrrabbit - it's customary to employ italics to convey emphasis; it's somewhat distracting when someone SHOUTS at RANDOM.

I know what chainline is, thanks. And biasing chainline by up to 3mm on a modern multispeed drivetrain, you say is equivalent to running in one gear all the time?

I guess if that's a pearl of wisdom, I'm a swine...

I'd say that depends entirely on which side of the cassette you hang out on most. Or even just how often you use the smallest cog.