I have used Panaracer Pasela Tourguard tires on several road bikes for the past 7 years or so. The most wear I have got from one of these tires is around 10,000 miles, a front mounted 700x35, which has only had a couple of flats in it's lifetime and no bad cuts in the tread or sidewall. It is still on one of my bikes, and the tread still looks good. As rear tires, they have provided me typically around 4000 miles of good use. I have had one or two of these tires mounted on the rear that lasted less than 4000 miles due to a bad tear in the tread or sidewall from a flat. If the tear or gash left from a flat is too big, I toss out the tire even if the tread is good because I don't gamble with my safety.
Panaracer has a newer model of tire called T-Serv which I have put on a couple of my bikes in the past year. It is almost identical in weight and design to the Tourguard, but is supposed to have beefier puncture resistance on the tread. On one of my road bikes which is also my primary commuter bike, the T-Serv 700-35 rear tire has gone about 2600 miles with no flats and very little sign of tread wear. IMO, the T-Serv handle and ride virtually identical to the Tourguard. A few weeks ago, a rear mounted 700-28 T-Serv on my lightweight classic Italian road bike flatted with a big nail that cut all the way through to the sidewall, and cut the sidewall for about 1/4". I made it home after fixing the flat, but tossed out the tire because of the risk of a sidewall blowout later. Bummer, that tire did not give me 1000 miles, but it was plain bad luck because stuff like that just doesn't happen very often.
In the future I'll keep buying either Tourguard or T-Serv because both are good tires and I am comfortable with them in terms of flat protection, handling and safety.