One great thing about the early Selle AnAtomica saddles is that they gave you an excellent and very detailed guide to saddle setup. I think he addresses the pressure you have very directly.

1. Height - measure your pubic bone height (not your trouser inseam) and multiply by 0.883. If you have crank lengths other than 170, adjust accordingly. This formula height is just a starting point.
2. Fore-aft - if you don't have any idea what your fore-aft position should be, make the axis of teh seat tube intersect the saddle top at the midpoint of the saddle. Otherwise use your current position. From here I like to slide the saddle fore or back (usually back) until my body can be comfortable when my balance is over the BB. In this position I can lift my hands off the bars without a big effort from my core to hold my body up. If I don't have it back far enough, I could feel pressure on the backs of my upper thigh (I think this is the problem you're describing. Eventually it will cause an internal bruise on my hamstring. I slide the saddle back far enough to minimize or eliminate this pressure without ending up with my weight supported on my perineum. If I have no upper hamstring pain, my sit bones are not on the rigid steel heel, and my perineum is not supporting my weight, it's good. Usually in this state my sitbones are even with the widest portion of the saddle.
3. Tilt angle - sitting upright on the saddle it should not take a large core effort to hold your butt in the position above. If you slide forward, raise teh nose a teeny bit at a time. If you slide backward, lower the nose a teeny bit at a time. You did install the saddle level in the first place, right?
4. If back of thigh pressure is more on one leg or the other and it would not be right to move teh saddle back again, you can rotate the saddle nose toward the side that has excess pressure, perhaps a 16th inch at a time. It may be necessary to adjust fore/aft after you do this. If you have excess pressure on one of your two sit bones, rotate the saddle nose toward the side with the pain, just a tiny bit at a time.
5. Tension - this is only really applicable to the Selle AnAtomica. I don't recommend tensioning a Brooks up and down in order to optimize it. It isn't designed for that.

The rotation adjustment was new to me when I started using these saddles, but I've used these concepts to help my wife and some others optimize saddle positioning with good results.