The difference isn't as big as you might expect. Also, my 4 Seasons are 700x28 and my 4000S's are 700x25, so there's some difference there. Generally, I think the 4000S's feel a bit sportier, but that may even just be a placebo effect. If they weren't on different bikes and I were just choosing one tire for all conditions, I wouldn't hesitate to go with the 4 Seasons.