The wheels I used it on, when I went to true them after a few years, the nipples were so hard to turn that I soon rounded them completely. Not the desired effect.
This is the pertinent statement, I think. You want the nipples to be able to turn against the rim and against the spoke threads. A year or two from now you may still want them to turn.
Someone may correct me but I cna't imagine a spoke nipple unscrewing from the spoke by itself with normal use. Pressure from the rim strip should provide some level of friction.