I have an OMM Sherpa front rack on my MB-2, which is my "bikepacking" bike. I also have a smallish-to-medium sized saddlebag. No rear rack. All my tools and dense, small objects go in the saddlebag, and my food, clothes, and UL tent/pad/sleeping bag go up front in my Carradice Super Cs. It's been a great rig, but I've used it only on 1-2 night trips in the hills around here. Mostly on trail. It's definitely a bit more "twitchy" when it's loaded but nothing you won't get used to. If you're using a Tubus lowrider it should be less noticeable.