US 50 is on the Adventure Cycling "Western Express" route. I don't have personal experience riding it, but IIRC there are two or three days with 85ish miles between water resupply points. Lots of info on the map if you buy it, lots of journals on crazyguyonabike. People do it, you do have to be careful. I would NOT do that mid summer, fall and spring would be much better. It does snow there in winter, as well.