I actually get this with my current job...
Sometimes you just need to stop and stay for a bit. My old position I would go to a location and work for 3-6 months at a time. Now I travel constantly. On more than one occasion I call the boss and tell him I am taking a few days off, sometimes I go home, other times I just stay where I am at and my bride flies in and we spend a few days enjoying ourselves in a nice place. FWIW she travels for her job too, as a Sr Flight Attendant.
And yes I did get this on my long tours, I would just settle into a place for a week or so until the itch to move got stronger.
Aaron