Depends on the case. I find that for me, I have to remove the saddle to pack my Brompton into the B&W hard case, and yes, mine has the rack and EZ wheels. The back rack adds that little bit of extra bulk. My wife's Brompton does not have the rack so I can usually pack her's without removing the saddle. If you have a softer case, you can probably get away with not removing the saddle. Removing and re-attaching the saddle is a bit of a pain, but no more than 2 minutes worth of work before and after your trip. In the attached picture, my saddle usually goes underneath the seat tube, tucked partly into my helmet void (you probably can't make it out - I put it in a plastic bag to prevent scuffs).