The vast majority of gun related deaths in the U.S. are based upon illegally owned guns--in most cases criminals shooting other criminals.

The vast majoirty of legal self-defense uses are among folks who were not carrying concealed--ie, defending their home. The percentage of legal concealed carry owners who have needed to use their weapon in self-defense is very low. The percentage that have used their legally carried weapon illegally (brandishing or actual firing) is even lower. Lower then the their relative percentage when compared to the otherwise law abiding general population (ie, remove the prior criminals).

I suspect this is because no one gets such a permit without a cursory introduction to the increase liability carrying a weapon entails; both criminally and civilly. One statement from my CHL instructor still reverberates in my memory. If you need to use your weapon, even assuming that you are found to have been justified, you can expect that you it will end up costing you between $30,000 and $50,000. These costs can vary from legal defense costs for criminal and/or civil charges. And that assumes you are found to have been justified in the use in the first place and that there is no 'political' reason for the prosecution. The anecdotal evidence is that a concealed permit makes it less likely to actually use the firearm when compared to those who don't have the permit.