A few months ago I got food poisoning while at work. My commute is around 15miles through LA, lots of starting and stopping, and no private places to hide to release yourself. I ended up getting much to sick to ride, everything coming out of me and the chills and shakes. Luckily my girlfriend came and got me, even the car ride home I could barely focus on anything but keeping it in me and not all over the car. If she wasn't around and no other friends/co-works that could give me a ride, i'd probably wait the worst of it out at work and take the bus or cab home.
Other times I've just not felt great, where I wasn't actually expelling my insides and usually I feel much better once I start riding.