I have only used three different tires on my hybrid in my limited experience. The Michelin Pilot Sports are my fav
http://www.amazon.com/Michelin-Pilot.../dp/B002Z7EE0I I've put a couple, maybe three thousand miles on them. They handle superbly. No flats, but I figure that's as much luck as anything. I picked up a flat on my first ride with a Bontrager hardcase which should have offered more flat protection than the Michelins, so... They're a sweet tire though. Two thumbs up.