Originally Posted by
achoo
There are also pedal/ground clearance issues with smaller wheels.
Not if the frame is designed for that wheel size. My bike with 20" wheels has the same pedal to ground clearance as my 700c bikes.
In addition to smaller wheels having less wind resistance, a smaller front wheel also allows the rider to draft more closely behind another rider in a paceline. But, as already mentioned, there are drawbacks in rolling resistance and ride comfort on rough roads. In comparing rides with my 20" wheeled bike to those with 700c wheels I find both the advantages and disadvantages to be rather minor.