I had the dropouts on my steel frames opened to 135, both road and mountain bikes. With the 135mm hubs I can minimize dish about as much as I am going to be able to do. In the last couple of years I have gotten one new bike frame and rebuilt a couple of my older bikes. What I did for my 26” wheeled expedition touring bike was 40 hole White Industries hubs, front and rear, with Velocity Aeroheat rims (they are the same extrusion as the Dyad rim). They were bullet proof. I toured for the first time with no wheel problems.
The new frame I got was a Salsa Vaya. I wanted to try disk brakes. They work great and White Industries makes similar hubs for disks. I have two sets of wheels for it: Ride2 hubs with Velocity Dyad rims and White Industries hubs with Velocity Deep V rims. Both are working just fine with 9 spd cluster setups.
My older Holland’s touring bike has 48 spoke Phil Wood hubs with Sun Rhyno Lite rims. This is probably overkill. It is heavier than is really necessary, but it is certainly bulletproof. With fast 700x37c tires it doesn’t seem to mind the slight excess weight of the rims.
I just finished rebuilding my criterium racing bike. It is 35 yrs old and after I stopped racing hasn’t been ridden much in that time. I put a pair of 40 hole White Industries hubs with Velocity Deep V rim wheels on it. It is certainly fast enough; faster than any of my other bikes. I am riding it on a Metric Century on Sat. I don’t expect any problems with my wheels.
I neglected to mention that I weigh 265.