I think you want the hoods positioned and the handlebars rotated to provide the most relaxed, natural position for your wrists. I you ride in the drops a good deal I would deal with that position first by rotating the handlebars and then position the hoods on the bars to achieve a natural position on the hoods. The result may not be a relatively straight line along the handlebars to the hoods, but this area may have to be compromised.