stumbled on this thread a bit late to the party but I think I can add a few things as I've been researching tubeless for the last few weeks and just took my first ride on a cx tire with them.
1. Can you use any tire in a road tubeless setup? NO! DONT DO IT! DONT THINK ABOUT IT! at high pressures the tire will blow off the rim. i set up my 32c cx tires today and initially inflated to 80 psi fully planning to go down from there. i was sitting on my couch chilling when BLADOW!!!!! Sealant all over the place!!!! The cx tires I was using are NOT tubeless ready but are widely known as able to work fine with tubeless setups however normally a CX rider would be running between 30-40psi. I was under the incorrect impression that I needed to initally inflate to a higher psi for a couple of hours to really make sure the bead sealed. That was erroneous info that I received from 1 source. you only need to get high pressure to get the inital bead seated and you will hear the tires POP.
2. Hutchinson intensive 25c road tubeless tires are widely known as still only being a 23 c tire much to the chagrin of everyone. The whole "hutchinson is ocming out with a 28c tubeless road tire" rumor has been going on for a couple of years. believe it when you see it. With that said, the whole thing about tubeless is that you can safely run much lower pressures without fear of pinchflatting so I'm a bit surprised that so many people say they want a 28c tire for tubeless as its like pulling teet to get any roadies to put a 25c regular tire on.
3. I'm 250lbs. I want a large sized tubeless road tire just so I can try to get somewhat close to the comfort that a 150lb rider currently has on a 23c tire. Tonight I put a 32c CX tire on the front of my surly disc trucker and inflated to 45psi. I'm so used to running high pressures that I was curious how this was going to go over (I normally run a 700x40 randoneur hyper at 80psi on this bike so to go with almost half that pressure in a 32c was a big step for me!) IT worked out great. I didn't suffer much loss of speed with a CX tire vs a slick because the lower pressure gives the tire a great contact patch with the road. When I hit manhole covers with deep grooves I cruised right over them with zero issues instead of getting my bones jarred. this is a GREAT thing as a commuter in NYC. At my size, I'm always feeling the need to swerve around potholes and other road hazards. When there is a lot of traffic, you can't always swerve around things confidently and safely. It's very nice to know that I can ride right through things with no issues.
4. Can you trust sealant to seal flats? Well i've only ridden tonight on this setup, but I've used sealant inside of tubes on my tubular road wheels and yes, sealant works pretty well to seal up holes, especially if you aren't pumping your tires up over 100 psi. there are conflicting stories about what sealants do what best but most people seem to say that stans is the best. If you ride a regular tubed wheelset and have a removeable valvecore that also has threads on the entire valve, i recommend you buy the stans sealant and syringe and inject 30ml into your regular road tubes. you will be glad you did! the stuff works!.
5. whoever said it takes longer to set up a tubeless tire is full of it. its really simple. put the bead on one side of rim. put the bead on the other side leaving all but the last 7 inches . pour 30-60ml of sealant into the tube. rotate tire a little bit and finishing putting the bead into the tire. Hit the tire with a compressed air til the bead seats and you are good. Top off with a hand pump the appropriate pressure as needed.