2 panniers
Map case with pouch instead of 1.5lb handlebar bag
no fenders
down quilt instead of sleeping bag
Click Stand instead of kickstand.
Lightweight running trainers instead of cycling shoes, cleats, and second set of off-bike shoes.
Minimal clothing
Lighter tires
On a long tour have some consumables (e.g., daily disposable contacts, maps) and cold weather gear mailed to me at halfway point or when needed.
iPad or iPad mini instead of laptop.
Audiobooks or ebooks instead of physical books.