Originally Posted by Myosmith

IMHO Slime is the ectoplasmic embodiment of pure evil. It does a poor job of doing what it is supposed to do (prevent flats), adds a lot of unnecessary weight in the worst possible place (the rims), plugs valves, and is a PITA mess to clean up when you do get a puncture or worse, a blowout. Just use decent quality tubes in the appropriate size. If you are worried about flat protection get flat resistant tires or a tire liner. I recently tried a pair of Schwalbe tubes which are supposedly higher quality than the stock Q-Tubes or other store brands. I haven't ridden them long enough to see any difference and I may not because I honestly get very few flats and those that I get are usually from road debris penetration that no tube is going to withstand.