Biking on the controlled-access highways, including the Interstate System, might be safer in some cases. There is usually a wide, 12 foot, shoulder, with no traffic.
Since the cars are moving so fast, the drivers don't have any time to hassle you. If you can learn how to cross the on and off ramps, it's no problem, especially if you need to get somewhere fast.
I use a rear view mirror and foam earplugs.