Originally Posted by Bill Kapaun

It might, but you'd have to try all the various combinations for a couple weeks at a time to find out. It's not really cost feasible for most of us.

I'm around 5-11" (down from a scant 6-1" in my youth) with a relatively short inseam of around 30-31"
My R knee doesn't have full range of motion, so I HAD to go to shorter cranks. I've settled on 165 MM after experimentation. My results were-
Length----Cadence
175---60 constant knee pain and my foot would come off the pedal @ 12 o' clock and 62 RPM
170---80 occasional knee pain
165---85 no pain
160---82 simply getting too short for my chubby legs