It's a good idea to make sure the saddle is in the right position
I believe I have tried every position available except backwards on many standard sorts of saddles and they are all uncomfortable at any angle. It was the first thing my brother suggested is that it is in the wrong position, but I must express how thin I am and that my bones then nerves rest on the saddle and I lose feeling very quickly, I have very little fat of any sorts, especially my bum!