How much do you want to spend? I can tell you the cheap version because I'm cheap! My entire lighting system cost me $100 AND I have had motorist tell me how well they noticed me compared to others riding bikes and appreciated my lights.
The headlight is a Cygolite Metro dual beams with a total of 13 watts, but it's not everyones cup of tea because it runs off of 6 D batteries for up to 5 hours (either throwaways or rechargeables); I liked the idea because I'm not tied to a wall and can buy batteries anywhere should they go dead on a ride. The cost-$48. (You can option up to a CygoLite Night-Explorer with 25 watts and rechargeable battery for $100).
Next up front is a Vistalight Xenon amber flasher because bicycle headlights are too small in diameter to attract attention no matter how bright of a light you buy, so a flasher gets their attention; the cost-$12.
The rear taillight is the Cateye LD600 LED, very bright and visible from at least 180 degrees off center if mounted vertically; the cost-$20.
Next for the rear is a pair of barend plug lights, single bright LED that goes in the end of your bars; the cost-$18
Total cost for lights: $98 plus tax; if you option up for the brighter headlight your at $149.
I also use wide reflective leg bands-one on each leg, and have reflective striping on my seat bag and helmet...but reflectors do not work as well as lights, their just added safety.