I would suggest that you test ride both bikes a couple times, and side-by-side if you can, before you decide. And don't just go by the specs on a datasheet. I very much agree with Christobevii3 that "all those little differences add up to quite a bit different frame", and what will be required on each frame to achieve a proper fit for you can vary greatly as well.

My Synapse is my "relaxed-fit" road bike that I have equipped with a 34t/50t crankset, an 11t/28t cassette, and a bit more upright positioning, and I use it for longer more relaxed rides like centuries or day-touring, and my Salsa Campeon is my "race-fit" road bike that I equipped with a 39t/53t crankset, an 11t/24t cassette, and a bit more aggressive forward-leaning position, and I use it for shorter, faster group rides. On paper they don't look too different, but on the road they are night and day.