I think all you can do is try different saddles, find out things that work and don't work about particular saddles and narrow down the s. earch.
I've been riding a 143mm toupe. sit bones are fine but get chafing where my bottom meets the thighs from rubbing over the saddle where it flares out. Did go through a retul fit so assume the saddle height is close.
I just put a cobb saddle on the other day and spun for 15 min on the trainer. Although it's narrower is still seems to support sit bones fine and the lack of a sudden flare out at the rear may help but this model "v flow max" is too wide in the nose for me I think. need more ride time.
Has anyone else had experience with Cobb saddles? They also seem kind of heavy, but comfort may have to trump that.