I found no problems with the BoB Skewer that the trailer tows by, interfering with my RD,
or racks and panniers.

But I'm not there to supervise and see what you are doing..
Summer Touring, we see lots of those Trailers being Towed,
Often without panniers on the bikes, maybe a HB Bag for convenience..
You should have enough space unless going off for
years at a time and carrying a week + of food.