I'm not completely sure what OP is asking, but here is the simple answer to what I think it is. The frame is always symmetrical, the rim is always centered in the dropouts, but the wheel is not symmetrical due to dishing. Amount of dishing depends upon the size of the freehub on the DS and design philosophy regarding placement of the NDS flange, but these days you would need a really wide OLN to avoid dishing completely (or asymetrical rims, very different DS and NDS flange diameters, etc.).

When I say the frame is symmetrical, I am talking only about the spacing being centered on the center line of the bike. Many new frames have different design stays on the DS and NDS to resist frame flexing under heavy load. That doesn't affect the centering of the wheel, however.