I'm 10 miles each way from Brooklyn to Midtown Manhattan. One would think that this is an urban nightmare, but you'd be wrong. I'm on separated bike lanes almost the entire way. The few sections where I'm with cars isn't all that bad either. I'm not a big Bloomberg fan, but I think he did a decent job with the bike lanes even if I don't like the design on some of them.
Am I tired after the ride in? Not at all. It's actually invigorating. I always look forward to the ride home.