I use two mini u-locks.
One from the front wheel to the frame and the other for the rear wheel and frame to whatever i'm locking it to.
That makes the main parts pretty much safe.
As a general rule, I stay away from all things quick release.
There is no real way to make your bike 100% safe.
If a thief wants it badly enough, he or she will get it.
But I feel like the measures I go to make it as unwelcoming as possible.