use a mirror, watch cars like a hawk, and get ready to bail if necessary.
control your speed on descents - nocturnal animals are probably a bigger danger.
choose your routes carefully, if those decisions are in your hands, that is.
I feel that steady lights are easier to track than blinking ones, although blinking lights are better at getting people's attention. Rural roads with drivers going at high speed favors the former, and urban settings with lots of light pollution require the latter.