There are far fewer events of this length/difficulty in the eastern US than out west; this particular one is not well known and appears on few calendars, so I thought I would post a basic info thread-
It's a timed race that starts and finishes in Boone, NC. Traverses gaps into Tenn and VA. May be entered relay or solo.
I've spent a lot of time biking in the appalachians since I live in Georgia: this is the best one I've ever been on so far. Is also probably the hardest, solo.
http://blackandbluerelay.com/