I'm an MTBer so take this for what it's worth:

When I started I had sit issues. My first 16mile ride ended in severe pain and I started to wonder if I want to continue doing this activity that is obviously causing me so much "bad" pain (muscle pain good). After I snapped out of it I hit amazon and got myself the following:

Pearl Izumi Men's Liner Short (I wear loose wicking shorts over)
http://www.amazon.com/gp/product/B00...?ie=UTF8&psc=1

Anatomic Relief Saddle with Gel
http://www.amazon.com/gp/product/B00...?ie=UTF8&psc=1

About a month later and I don't feel any discomfort at all unless I do something stupid (happens).

The liner shorts really keep things where you initially put them, When I get on the bike I adjust then forget about it. The anatomic seat really helps put the weight on my sit bones.